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Microbe-Lift Broad Spectrum Disease Dosage Pond Size (gallons) Dosage Any Add 3.5 oz. per 1,000 gallons of water Prior to initial use and each of the 3 applications, at least a 20% water change should be made. A nearly total water change (>90%) will greatly improve effectiveness. Carbon Filtration must be removed and UV's turned off during treatment. Treat once a day for 3 consecutive days.